Penicillin is one of the most popular antibiotics but it is also one of the most common drug allergy causes. The effects of this Penicillin allergy include wheezing, hives, and more. Scientists have linked this Penicillin allergy with a genetic variation on the immune system gene HLA. Genetic variations within this gene were also linked with adverse reactions to HIV/AIDS medicine. To find this correlation between the variation in the HLA gene and allergy to Penicillin researchers looked through genetic records of people who reported that they shared this allergy. The researchers combed through the DNA of these people and found one thing in common among all of them, a variation on the same spot of chromosome 6. This variant was named HLA-B*55:01. These findings were then confirmed when researchers cross referenced their findings with genetic data from "23 and Me" that further confirmed the genetic variation in the HLA gene. Scientists are optimistic about these findings because they can use them to help people overcome their allergies to Penicillin and other antibiotics. Scientists now need to come up with a way to override the variation on the HLA gene in chromosome 6 to prevent this resistance from occurring.
Article Link: https://www.sciencenews.org/article/penicillin-allergies-immune-system-genetics
Related Link: https://www.sciencedirect.com/topics/medicine-and-dentistry/penicillin-resistance