According to the University Medical Center Gottingen, heart problems cause disturbed gene activity in the brain’s memory center. Using mice models, the researchers found that heart failure leads to specific changes in the hippocampal gene expression. This gene directly affects the hippocampus which is a region in the brain that is linked with learning. The changes reflected caused an increase in cellular stress pathways, which eventually lead to loss of neuronal euchromatin and reduced expression of a hippocampal gene cluster essential for cognition. Researchers still do not fully understand why heart failure affects gene activity in the hippocampus.