In "Genetic or immune defects may impair the ability to fight Covid-19," it brings in thinking of some reason of how. Many of the life-threatening cases were people who had genetic or even immune defects that caused them not to be able to fight Covid-19. The organization, Covid Human Genetic Effort, had brought up the fact that there are glitches in the severely ill-patients in type 1 interferon. Type one interferon is a molecule within the immune system that detects infection and stop it from continuing that does the same with viruses. In one, the severely ill patients have a mutation that makes it so they can't create the interferon. In the other, they found that the severely-ill Covid-19 patients had an antibody that connected to the interferon stoping its actions. In both cases, it causes severe effects on the patient due to genetic/immune defects.
I believe that there are many ways that the severely ill Covid-19 patients could be in their position though a big one could be the immune defects and genetic effects. The reason I believe this is because the immune system helps fight off anything that can harm us. But if there is a genetic or immune defect, it could not function and let the virus is due to it not being able to fight the virus.
https://www.theguardian.com/world/2020/sep/24/genetic-immune-defects-may-impair-ability-fight-covid-19
https://www.covidhge.com/
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