Friday, November 29, 2019
Brain Tissue Reveals Sex-specific Gene Changes in Depression
Major depression is a mental health disorder where depressive symptoms continue for at least 2 weeks. A study was done in which researchers analyzed brain tissue of 26 deceased adult men and 24 adult women who had major depression. They specifically searched for genetic alterations across the dorsolateral prefrontal cortex, subgenual anterior cingulate cortex, and basolateral amygdala, all of which are implicated in depression. The study reported 706 genes expressed differently in men with severe depression and 882 genes expressed differently in women with the disorder. The researchers also note that the different brain regions are unique to the opposing changes in gene expression.
I thought that this article was cool because special medications could be created specifically for each sex for the most effective results. Sometimes antidepressants are not effective for certain people so I hope that this study will become useful for them.