Thursday, October 4, 2018

HIV’s gene Protein TSG101

HIV is a one of the most deadly diseases that is still around in the world. New studies have identified PhysioGenetics as the pathway to follow to drive away this virus from healthy cells. Like it is to be expected, physiogenetics is being implemented in public health and investigation programs. HIV is more than just one simple lethal disease. It’s unique characteristic presents unique ethical, legal and social issues. Thanks to todays technology we are able to start identifying the gene that is infected. Thanks to this we are able to identify the infected cell and control it until it reaches the cell membrane so that it can be extracted from a cell.

We realize when the viral protein Gag and gene protein 101 (TSG101) is identified using todays technology. This gene is the gene in charged of multiplying the cycle for the HIV-1 replication. It approaches using a cellular endosomal sorting complexes required for transport (ESCRT) pathway, this allows for HIV infected cells to be localized easily and be treated with therapy. When the infected cell is localized with the gene (TSG101), this gene can be treated with the enzyme-linked immunosorbent A (ELISA). This enzyme identifies compounds that inhibit HIV-1 replication when target Gag-TSG101. There are two hit compounds which are HSM-9 and HSM-10. So, this compounds have an antiviral activity against CD4+ T cell-tropic NL4-3 and macrophage-tropic JR-CSF HIV-1 strains. This results stablished the system of HTS being indispensable to identify HIV-1 Gag-TSG101 interactions inhibitors.
Lancet HIV. 2018 Aug 30. pii: S2352-3018(18)30134-6. doi: 10.1016/S2352-3018(18)30134-6
Biochem Biophys Res Commun. 2018 Sep 18;503(4):2970-2976. doi: 10.1016/j.bbrc.2018.08.079. Epub 2018 Aug 17

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