Researchers found that a specific gene mutation of a gene ATRX it can lead to pancreatic cancer or pancreatitis in females.
The researchers deleted the gene they studied the female preclinical model and found an increase in susceptibility in pancreatic cancer but when the same gene was deleted in males then it showed a decrease in cancer.
So this is a sex-specific gene mutation.
In a follow-up study, using tumor samples from French patients the researchers are trying to better understand this mutation.
"The loss of ATRX increases susceptibility to pancreatic injury and oncogenic KRAS in female but not male mice," is published in Cellular and Molecular Gastroenterology and Hepatology.