Major depression also known as major depression disorder is when symptoms of depression last for 2 weeks. Statistics show that women experience this type of depression more than men in fact women are twice as likely. Scientists wanted to find out if there was any genetic difference between men and women when it came to major depression. In a study, Dr. Marianne Seney, Ph.D., from the Department of Psychiatry at the University of Pittsburgh Medical School, pinpointed these differences.
In this study they analyzed the brain tissue from 50 deceased adults who had major depression as well subjects without major depression. There were 26 men and 24 women who made up the 50 subjects who had major depression. Scientists wanted to see if there were any genetic alterations in the three brain regions. It showed that " 706 genes that were expressed differently in men with major depression and 882 genes that were expressed differently in women with the disorder. There was few gene expression changes shared between mean d women. The scientists identified that 21 genes were altered in the same direction.
Dr. Seney and other scientists who he worked along side with concluded that since they had focused solely on postmortem brain tissues that they were not able to clarify if whether the opposing gene expression changes they identified led to differences in how major depression affects men and women. However they believe that what they discovered in this study suggests that men and women may still require different treatment approaches when it comes to major depression.
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