Sunday, November 26, 2017
The most popular genes in the human genome
This article is about the many human genomes and how of all the genomes in the human body, very few of them have a majority of research done for them. Peter Kerpedjiev decided to catalog and systematically tag every paper in the PubMed database. From there he compiled the most researched genomes in humans. One genome in particular has some 6,600 papers written about it, and continues to have about 2 papers coming out per day. That genome is TP53. This gene is specifically referred to as the the guardian genome, as it is known as a tumor suppressor. With the increase of cancer research over time it is no wonder that this is an extremely researched gene. Over the course of Peter's cataloging, he noticed that out of 20,000 or so protein coding genes, just 100 account account for more than a quarter of all papers written. Second on that list of the most popular gene in the human genome is the TNF gene. TNF stands for tumor necrosis factor, and is a common drug target for cancer and inflammatory diseases. I think this article is interesting because there is a great deal of research being done in all areas, but with so many papers coming out about the same topics, maybe more research should be done elsewhere. It is extremely important that scientists zero in on the important genes, but maybe more answers lie where everyone isn't looking.