Recent studies in genetics have
discovered new targets to reduce heart disease. A new mutation in the PCSK9
gene has been discovered that is common in people with heart disease. People
who have this mutation in this gene have shown low levels of bad cholesterol. With
this discovery, new medication that act as PCSK9 inhibitors have reduced the
bad cholesterol in people that have high levels. Researchers have confirmed
that these inhibitors have reduced the risk of a stroke or heart attack by 15
percent in people.
The
mutation in this gene plays a role in breaking down built up plaque in people’s
arties which reduces the risks of a stroke or heart attack. People who have
unhealthy bad cholesterol levels tend to have plaque built up in their arteries.
Another
gene that has been studied is the APOC3 gene. Studies have shown that the
absent of this gene reduces the risk of heart disease and the common side
effects of heart disease like strokes and heart attacks. Researchers in the
Radar lab tested the absence of the APOC3 gene in mice and discovered that
lower levels of APOC3 protein lead to a lower risk of heart attacks and
strokes. This is because the antibody that targets this protein was able to
break down the triglyceride-rich lipoproteins.
This
is a promising study since it can lead to new advances in medications that can
help reduce the risk of heart disease and reduce the risk of heart attacks and
strokes. With this, researchers will continue to study the genes that are
common in heart disease and make new advances in medications and precautions to
help reduce the risks of this disease.
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