In
recent study, researchers found a certain characteristic of bovine antibodies
which allow cows to generate broadly neutralizing antibodies against HIV. The
broadly neutralizing antibodies can terminate infection from a wide array of
HIV types. About 1% of HIV-infected humans develop these antibodies, but it can
take several years. The antibodies that people develop are specific to one
strain of infection and are ineffective against other strains.
Broadly
neutralizing antibodies have a stretch of amino acids that stick out from the
antibody surface, which can penetrate the coat of the HIV surface. Humans
infected with HIV who can develop these antibodies have a region called “HCDR3”
which is typically 30 amino acids in length. The length of the amino acid chain
for cows is relatively much longer, and that’s what led to the idea of
immunizing cows.
Four
cows injected with several types of HIV proteins produced antibodies to fend
off the virus as soon as 42 days after immunization. The researchers tested one cow’s antibodies
against many other virus types, and after 381 days the cow’s antibodies
prevented 96% of 117 HIV types. If it’s possible to implement the antibodies
with long HCDR3s in humans then it’s possible for the vaccine to help prevent HIV.
This would be a major advancement in the world of HIV and could possibly change many lives. I wonder if there is a way we could help the body make its own antibodies after figuring out how to inject the bovine antibodies.
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