If you’ve ever taken a biology class whether in high school
or college, then DNA replication should be something you are already familiar
with, but just incase that file is somewhere lost in your memory bank, here’s a
quick reminder on how DNA replication works. The DNA strand replicates by
unzipping its two intertwined strands and makes copies of each strand. Sometimes
these strands run into obstacles such as lesions that block the strands
progress. Now that we’re all caught up on how DNA replication works, lets discussion
the importance of lesions. These lesions that DNA runs into pose a serious
threat to our cells, but as wonderful as the human body is, our cells have
evolved a marvelous mechanism to cope with these lesions. Usually after a
stressful day or period of time, we naturally tend to do something to get our
minds off of stress: going to the mall, watching a movie, taking a hot shower,
or meditation. Our cells have a different approach when they deal with
replication stress. The cellular stress-busters include fork repriming, fork reversal, fork degradation and backtracking, replication-fork breakage, and replisome dynamics during replication-fork restart (Vindagni 2016).
These forms of “stress-relief” for our cells allow them the opportunity
to fix the obstacles in their paths and avoid passing along genetic mistakes to
their daughter cells. The effects of improper repair of DNA lesions include
loss of genetic information, mutations, abnormal chromosome structures which
can result in premature gaining, cancer, and genetic abnormalities.
Click here for original source: https://www.sciencedaily.com/releases/2016/03/160328195128.htm
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