Ceasing to
smell one’s perfume after constant exposure while people walking by can still
smell it is just one case of a phenomenon called olfactory adaptation. A similar fading of odor signals with continuous
exposure also happens in animals, and scientists often depend on animal studies
to try to understand the cellular and molecular bases for the condition. This is
useful because it allows animals to sort out the indications of a new odor from
the background noise of constant odors. It may also permit them to sense when
an odor grows stronger. An identified chemical that acts as a gatekeeper for
neurons involved in smell, opening and closing their electric signal channels.
Genetically engineered mice that did not produce the substance, a protein
called CNGA4, had profoundly impaired olfactory adaptation. A separate
test-tube study found similar changes on a cellular level, with the signal
channels remaining open when CNGA4 was absent. Hopefully
this research will one day allow people to not forget the smell. The mice do
not produce CNGA4 so they can handle it. Maybe one day after more genetically
testing people will be able to smell fine all day without reapplying multiple
times and eventually having it to be overpowering to others.
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