Hearing loss can be caused by multiple sources: injury, infection, or genetics.The American Journal of Pathology published research on hearing loss caused by malfunctioning mitochondria. To test the mitochondria's role in hearing loss, mice were modified to have a gene which codes for mitochondrial TFB1M. TFB1M has already been researched and found to be connected to hearing loss. When comparing the modified mice with the control mice (mice with TFB1M and mice without TFB1M), researchers noticed a difference in the spiral ganglion nerves and the stria vascularis of the mice. Damage to either of these parts of the ear could cause severe damage to hearing. The researchers theorized that the damage to these regions of the ear were caused by reactive oxygen species produced by the enzyme AMPK. To determine if AMPK was the true causes of the damage, more modified mice with TFB1M with observed, but half of these mice had their AMPK minimized. The mice with less AMPK, experienced less damage to their spiral ganglion nerves and their stria vascularis. The determination that AMPK causes hearing loss could possibly help prevent hearing loss in the future.
Determining the cause of hereditary hearing loss was an important first step to developing a cure for this disease. Not only were the researchers able to confirm the mitochondrial gene which causes hearing loss, but they also determined the protein which is responsible for the hearing loss. Another important discovery made in this experiment was that the AMPK levels in the non-affected mice did not contribute to hearing loss. Since these two factors were determined, there could be two possible ways which cures could be produced. The first way is that the gene for this trait could be altered. The second and more realistic way is to create a medicine to minimize AMPK levels in affected people.