During the research, scientists took an epicenter from the super-enhancer and linked it to a gene, which would glow green when transcription factors were present. They found that in living mice, all of the hair follicle stem cells glowed green, but did not when the cells were removed from the follicle and placed in culture. Also, scientists found that some of the stem cells glowed green during a wound-repair when culture. The scientists concluded that Sox9 was the only transcription factor expressed in culture and living tissue and it is needed to prevent the death of the stem cells.
The study shows how stem cells response to different environments (culture or repairing wounds) as it maintains plasticity. Researchers studying Sox9 can use it to further the study of male pattern baldness. It could also aid in hair growth methods people who are balding.
Original link: http://www.newswise.com/articles/scientists-pinpoint-molecule-that-controls-stem-cell-plasticity-by-boosting-gene-expression2
Related Link: http://link.springer.com/referenceworkentry/10.1007%2F978-3-642-16483-5_5492
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