A new study has reported that a gene variant, KL-VS, is believed to play a role in longevity with individuals with the gene, as well as ensuring that they retain their intelligence. People that carry this gene variant have a larger volume in a front part of the brain that is involved with decision making and planning. They also perform better on tests that revolve around working memory and the brain’s processing speed, which usually slows down with age.
The specific gene involved is called KLOTHO, and it provides the coding for a protein, klotho, produced in the kidney and brain that regulates many processes. The KLOTHO variant, KL-VS, has been found to increase klotho levels, longer lifespan, and better heart and kidney function. Researchers conducted a study where they analyzed the brains of several individuals. They found that those with one copy of the variant gene had 10% more volume in the brain region called the right dorsolateral prefrontal cortex; on the other hand, the brain region shrank with those containing two copies of the variant gene or without the variant altogether.
Another study with mice demonstrated the same results. Mice with one copy of the gene variant lived longer and were smarter at baseline. Altogether, studies have indicated that KL-VS promotes slower aging of brain function enabling individuals to lead longer and healthier lives. There is also some evidence that this gene variant may perhaps lead to treatments that slow brain aging and help individuals who suffer from dementia.
Given the results and evidence provided by professional studies involving KL-VS, it is fascinating to see how a single gene can allow someone to live a longer and healthier life. Of course, environmental factors also contribute to how long one lives; however, a gene that can slow brain aging and boost structure and function might counter the effects of diseases affiliated with the brain and help give more effective treatments to people suffering from those diseases.
Given the results and evidence provided by professional studies involving KL-VS, it is fascinating to see how a single gene can allow someone to live a longer and healthier life. Of course, environmental factors also contribute to how long one lives; however, a gene that can slow brain aging and boost structure and function might counter the effects of diseases affiliated with the brain and help give more effective treatments to people suffering from those diseases.
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