However, the genome of mice can't be used to aid in the treatment in human disease in all cases. Two examples of systems that can't be compared between the two genomes is the immune system and response to stress. Environmental factors may have contributed to the differences between the mouse and human genomes. However, the ways in which genes are regulated are extremely similar; gene transcription and chromatin modification are two examples of gene regulation. Despite the similarities in these processes, they differed from one type of cell to the next. In one project, an author of Nature found several statistics that demonstrate the difference and similarities between the genomes. For example, after studying over one million locations of DNase 1, he found that approximately 35% of the information was the same in mice and humans.
Article: http://www.sciencedaily.com/releases/2014/11/141119132703.htm
Supporting Article: https://www.broadinstitute.org/scientific-community/science/projects/mammals-models/mouse/mouse-genome-project
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