The repairing of cartilage is a vital step in future medicine. The article written by the University of California. The University has been testing a theory on strengthening the cartilage. One of the major problems with joint transplants is that the tissue rejects from the body. However, if the tissue was from a native cartilage it would have a less chance of rejecting. Collagen a key component of the make up of cartilage that has the ability to have its cell fibers to be crossed -linked. The cross-link could be strengthen by the reduction of oxygen or the addition of the enzyme of LOX.
The tissues were engineered by initially immature native cartilage that are cultured with cartilage cells to create the engineered cartilage. Engineered and native tissues were both reduced of oxygen. The lower oxygen produced more cross-linking and tougher tissue. The data collected also displays that the enzyme called lysyl oxidase was created. This enzyme had increased the cross-link and strengthen of the tissue too.
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