Monday, October 20, 2014

Genetic Cause Found for Clogged Arteries

It is believed that blood pressure and cholesterol levels are not the most accurate way of assessing the risk of heart attack and stroke. Instead, it is now said that measuring calcium build-up in the arteries gives a better indicator of the likelihood of heart problems. Calcium build-up in the arteries marks the calcification of plaque, which results in hardening that can lead to heart attacks. Recently, it has been found that a genetic variation increases one’s risk of developing these deposits in the heart. This variation gives us essential clues as to how we should treat the disease that is found in nearly 7% of the world’s population. Wendy Post, from the Johns Hopkins University School of Medicine said “The latest findings could lead to the development of targeted medications to slow the progression of the disease, which can cause chest pain and shortness of breath, and can in some cases require surgery”.

 The gene that is currently being looked at is involved in the production of lipoprotein, a type of cholesterol particle that circulates in the blood. It has been said that high levels of lipoproteins are connected aortic valve disease. But, in previous years, scientists were not able to determine if it was just a marker of the disease or a casual factor. “Our results provide the first evidence for a casual relationship,” exclaimed Wendy. After surveying around 7,000 people, and looking at 2.5 million gene variants, it was found that the particular variant was strongly associated with the aortic calcium deposits.


When looking around for articles this one particularly caught my eye because a few years ago my dad found out that he had severely clogged arteries. After reading through this article, it was interesting to learn that a genetic variation could have likely been the cause for his blockage. With these new findings that there is the possibility for developing medications to target and slow the progression of the calcium deposits. It’s exciting that these findings have the potential to go on and affect the future of diagnosing and treating aortic valve disease.

1 comment:

  1. I think it is remarkable that scientists have now distinguished calcium build-up as the best way to assess the risk of a heart attack or stroke. The only methods that I have ever heard of that assess the risk of a heart attack or stroke are by analyzing cholesterol and blood pressure levels. This is a prime example of how science and technology continue to lead to new medical advancements. This new method of measuring calcium build-up could ultimately save the lives of many people. Every step forward counts, hopefully this is only the beginning of research in this area of the medical spectrum.

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