Crohn's Disease, a type of Inflammatory Bowel Disease, is a chronic illness of complex origins affecting approximately 100 to 150 people per 100,000. Understanding the genetic component of such complex diseases is central to explaining patients' symptoms and improving treatment.
Despite Crohn's having a large genetic component, this has been hard to dissect. This is partly due to the large number of genes involved, their complex interactions with environment and the spectrum of clinical presentations. As a result, many scientists have been focusing on ever larger cohorts of patients under the impression that larger data sets data will give better results.
http://www.sciencedaily.com/releases/2012/12/121213121805.htm
http://health.rush.edu/HealthInformation/In-Depth%20Reports/10/000103.ASPX
Despite Crohn's having a large genetic component, this has been hard to dissect. This is partly due to the large number of genes involved, their complex interactions with environment and the spectrum of clinical presentations. As a result, many scientists have been focusing on ever larger cohorts of patients under the impression that larger data sets data will give better results.
http://www.sciencedaily.com/releases/2012/12/121213121805.htm
http://health.rush.edu/HealthInformation/In-Depth%20Reports/10/000103.ASPX
Hopefully localizing the genes into smaller groups will help better treat this disease. There are so many different types of stomach conditions that it's so hard to sometimes differentiate one from the other given similar symptoms. Now that 200 genes were discovered to be involved with this type of disease and its large genetic component it'll be interesting to see if researchers can test these genes in babies to see if they will develop or have the disease. If they can, parents will be able to choose the right foods and diet for their children.
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