Thursday, April 18, 2013

Biomarkers That Predict Chemotherapy Survival

According to Medical News Today, a "signature" of eight genes has been found that can predict a cancer patient's likelihood of surviving chemotherapy.  This print can also predict the amount of relapse-free survival time a patient has.  So, how is it done?

A team of investigators from Academia Sinica and the National Taiwan University College of Medicine identified genes that participate in cellular invasion, which is a large property of most cancer cells.  The reactions of these genes to 99 different anti-cancer treatments was observed and eight genes were found that could possibly affect the impact of chemotherapy.  It was found that there was a noticable variation between cells that did respond to chemotherapy treatment and cells that did not respond to chemotherapy treatment.  (There was some overlap.) 

Other clinical studies were done on breast cancer and lung cancer patients.  It was shown that the patients that had the eight gene signature that placed them in the low-risk category had a longer relapse-free period of survival than those in the high-risk group.

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