Obesity Reversed in Mice by Manipulating Production of an Enzyme

Scientists at  Virginia Commonwealth University have reversed the condition of obesity in mice by manipulating an enzyme named tyrosine-protein kinase-2 (Tyk2). The researchers had discovered that Tyk2 regulates obesity in a type of fat tissue called brown adipose tissue.(BAT) It was discovered that Tyk2 was regulated in mice by diet. When obese human fat tissue was analyzed it became apparant that the levels of tyk2 were 50% lower or more drastic. There are two different types of fat; white adipose tissue(WAT) which is responsible for energy storage, while BAT is responsible for the regulation of energy usage.  BAT activity is associated with metabolic syndrome which could impact 25% of people. This news has came at a time where 68% of Americans are overweight or obese. Those with obesity are at higher risk for cardiovascular disease, cancer, and diabetes. By activating a protein signal transducer that activated an enzyme called STAT 3 scientists were able to elevate levels of Tyk2, which in return reversed obesity in mice.



As an individual that has seen the effects of obesity in the family the news of obesity reversal is great news. The ability to for an individual to become of healthy weight not only impacts life expectancy, but also the quality of life. It amazes me what science is able to do in terms of improving the quality of life, but also hits a soft spot inside when I am able to imagine my father to have an improved quality of life. Multiple attempts have been made to help the problem, but in the end obesity has the upper hand in the battle. Just the quality of life improvement makes this discovery one that has me smiling. The health impacts as well with the reduction of cancer, diabetes, and cardiovascular disease risk could help 68% of America.