Bdnf Gene Mutation Cause Obesity

According to Medical News Today, at the Georgetown University Medical Center researcher identified gene called BDNF which mutation cause obesity in human being. A studied on mice proved that a mutation causes failure of neurons to stop passing chemical signals which helps hunger to suppress. The importance of the bdnf (brain-derived neurotropic factor) is forming synapses which cause neurons to sends chemical signals to other neurons. However, Bdnf controls the leptin and insulin signals by brain neurons. Uncertainty, hormones do not affect the correct location in the hypothalamus when person eat, person would not stop eating.  

     A studied was proved by using two mice groups. A mouse has a gene mutation on Bdnf gene and the other with normal gene. Researchers measure the food consummation or body weight and the increases of obesity among mouse. Based on the study result was that the mutated mice body weight increased and mice became obese; while non-mutated gene mice does not showed any changes.  They said that if leptin does not trigger in the mutated mice; than the hypothalamus would not activate as if in non-mutated mice. A researcher believes that drug could be used to encourage the bdnf or “adeno-associated virus-base gene therapy”.  

    Overall, it is great that researcher find gene mutation of bdnf that is inked to obesity. In future, this gene mutation might be a big problem for obesity if it will not be identified.  Also, over weighted person could control their diet or do exercise daily  to prevent from obesity.