Wednesday, May 1, 2019
Using mRNA Molecules To Repair Heart Tissue
MicroRNAs function in the is to control gene function when the heart is developing. Da-Zhi Wang, Ph.D is a cardiology researcher at Boston's Children's Hospital and he is looking at two specific types of mRNA. He is looking at miR-19a and miR-19b.The findings could help prevent heart failure following a heart attack, which is, according to the researchers, "the leading cause of mortality and morbidity in humans." Wong and his team used a mouse model of a heart attack and delivered the mRNA and the results were positive.The first 10 days after a heart attack, the microRNAs reduced cell death and stopped the inflammatory reaction that typically damages the heart muscle during a heart attack. This research is promising and Professor Wong concludes by saying "MicroRNAs hold tremendous promise to become powerful tools to battle cardiovascular disease,"