Dual Action Cancer Killing VirusA big risk with cancer cells in the body, is that when they develop, they are able to trick adjacent cells into shielding the cancer from the immune system. Scientists have now programmed virus' that kill carcinoma cells or cancer cells with a specific protein which can also target and then kill the adjacent cells which are tricked into protecting cancer cells from the immune system and then killing all cancer cells in the body. Its the first time we are able to now take the cells that are protecting the cancer and remove them. They have already been tested in mice and cancer samples from humans and could be tested on live humans as soon as next year. The previous problem with this idea is that the fibroblasts who are tricked are not the only ones who are killed, other fibroblasts in the body are also killed which leads to toxicity in the body.
The new virus is called enadenotucirev and has so far only infected cancer cells and not healthy cells. The protein this carries is called T-cell engager and it binds to two types of cells and stick them together. The two here are the fibroblast and the other is T-cells. This then triggers the T-cells to kill the fibroblasts. When this was tested, it was tested on prostate cancer tumor samples which reflect the same makeup along with it being tested on healthy bone marrow to make sure it did not cause toxicity which it did not. Dr Michelle Lockley, an expert from the renown cancer research UK said "Using the power of the body's own immune system to tackle cancer is a growing area of research...one of the biggest challenges of immunotherapies is predicting how well they will work with the patients immune system, and understanding what the side effects could be." This type of virus could typically target specific cancers such as skin, tissues that line or cover internal organs, or pancreas, lungs, colon, breasts, ovaries, and prostate cancer.