Is Hyperhidrosis Hereditary ?

 

    Hyperhidrosis is a medical condition described as excessive sweating. Excessive sweating can occur on the hands, under the underarms, on the face, and more. Your environment can contribute to sweating such as high temperature or working out. However, when not in these conditions why might someone still be excessively sweating? Hyperhidrosis can be passed down through generations. About 35-55% of people with hyperhidrosis has at least one family member with the conidition. If grandparents, parents, etc have hyperhidrosis, there is a chance you will too. In addition, hyperhidrosis is an autosomal dominant trait that can affect either males or females. Furthermore, it has been noted and observed that hyperhidrosis excessive sweating symptoms don't occur until around the adolescent years. There are not many treatments for hyperhidrosis. Currently, there are internal medications and topical treatments all that require a prescription for use. I believe it is important to conduct more studies and research on hyperhidrosis. People with this condition may not want to use topical or internal treatment based on side effects so they have to continue living uncomfortably. Hyperhidrosis can lower self esteem as people may wear darker clothing or avoid social gatherings so their sweating isn't noticeable. 

Green Fluorescent Protein Biosensors Used to Detect Temperature in Thermal Homeostasis

Homeostasis is the one of the requirements to life. This property is occurring continuously in all living things. Specifically in warm blood animals, thermal homeostasis regulates body temperature. Scientists are interested in the measuring the heat generated from metabolic processes. However, it was not possible to measure the heat generated until researchers created a recombinant fusion protein. This kind of protein was created through genetic engineering a fusion gene, combining TIpA (a protein found in Salmonella) and Green Fluorescent Protein (GFP). TIpA can detect heat changes and attach to the region in the cell while GFP emits green fluorescence. By taking advantage of TIpA's behavior under different temperatures and GFP's ability to fluoresce, the researchers were able to differentiate between hot and cooler temperatures within the cell. According to Principal researcher Yasuo Mori, the next step of the research is to apply it to living model organisms.

Mechanism of TIpA in Hold and Cold Temperatures

Homeostasis is one of the fundamental processes that a living thing undergoes. To understand this process more can help human beings understand the building blocks on life. Sure, this study is only looking for temperature changes, however, I believe that with genetic engineering, other proteins can be developed to track other elements of homeostasis. By further understanding this  process, benefits could be seen to help people who have trouble regulating parts of homeostasis. One must also take into consideration that this is a very early study. But nonetheless, it has the potential to detail the steps taken within homeostasis and help scientists further understand this complex process.