Showing posts with label artificial gene deletion. Show all posts
Showing posts with label artificial gene deletion. Show all posts

Sunday, July 16, 2017

The Upside of Bad Genes


A recent article about the "Upside of Bad Genes" in The New York Times said there is a possibility of new developments that will allow doctors and scientists to erase/delete harmful genes all together.  The new technology is called Crispr-Cas9, this method is still a few years off from being used in clinical settings due to the fact that scientists are still unsure about unknown consequences.  While the ability to delete 'harmful' genes seems like an amazing concept; however, for people in sub-Saharan Africa can actually benefit from the "harmful" Sickle Cell gene.  If an imaginary couple had four children, one would most likely have Sickle Cell Anemia, but two of the children would likely have one Sickle Cell gene which will prevent them from Malaria, which is a big concern in countries like Africa and India.  This is also hypothesized for Cystic Fibrosis, two genes causes the disease, but one gene may be able to help prevent Tuberculosis.  The question now is, do we delete the gene even though it has helped in the past? This is a hard question to answer, and I don't think we have enough research to answer it yet.  In certain parts of the world people benefit from having one copy of the gene but the people that have two copies of the gene will continue to suffer; without the gene all together more people may become affected by the disease.

Thursday, December 4, 2014

Touch-Sensory Principle Protein Identified



The concept of touch and the mystery of how it is felt has always been a mystery in the scene of neuroscience. However, biologists at The Scripps Research Institute have identified a protein that brings about touch in mammals. Earlier in April 2014, TSRI was also the first to identify the dual-sensor system and nerve-touch sensation through relation to Merkel cells revealed by the supporting article. Last year, the same scientists discovered ion-channeled proteins Piezo1 and Piezo2 through studying its effects on mice. This year, they discover that only Piezo2 is the primary protein that when activated in Merkel cells, sends the feeling of touch through the nervous system. During the current study, they note that when Piezo2 protein is removed from newly bred mice (by deleting the gene!), all mice died at birth. However, when Piezo2 is removed during an adult stage of the mice's life, the mice is almost incapable of feeling light touches but still able to feel harsher pains through observation of reactions.

I found these articles interesting because I love any science that deals with the 5 senses because of the science involved that produce these sensations and now can come closer to understanding human existence. This neuroscience study included parts where scientists actually removed a whole protein gene from the mice which I found was interesting. The concept of touch can now be applied to how light and other sensations felt by touch can now be studied through these Piezo2 ion channels. I cannot wait for the next big discovery TSRI has to offer. 

Original: http://www.sciencedaily.com/releases/2014/12/141202161427.htm