Showing posts with label Helicobacter Pylori bacterium. Show all posts
Showing posts with label Helicobacter Pylori bacterium. Show all posts

Thursday, November 27, 2014

Developed Lipid Particle to Fight Gastric Ulcers and Cancer



A bacterium called Helicobacter pylori causes peptic/gastric ulcers, and gastric cancer has been countered by using a newly developed lipid particle with its main ingredient being found in vegetable oil that's called linolenic acid.

The University of California, San Diego Health Sciences has released their results and proved that LipoLLA, the lipid, that contains the linolenic acid found in vegetable oil, has been verified safer and more effective at battling these gastric cancers by testing the H. pylori bacteria in mice rather than normal antibiotics. This particle is defined as a nanoparticle in the field of nano-therapeutics. What it does inside the body is it attaches to the bacteria (membrane-wise) and then the linolenic acid disperses in the bacteria and kills it. The team figured out that by feeding micefluorescent markers to tract the LipoLLa, they measured the bacteria that was left and compared it to the use of normal antibiotics.

However, this is not the first time scientists found a way to stop this bacterium. In Southern Medical University in China, researchers developed an oral vaccine that was also tested in mice.

I found this article interesting because I would not even think to begin to suggest an ingredient found in vegetable oil to come closer to fight cancer and ulcers. The key fact is that the LipoLLa was proven that it would not harm the mice and virtually makes it a safer and more effective drug than normal antibiotics. The brilliance of these scientists is incalculable because they seem to find something new everyday. I'm guessing somewhere in the near future that they'll figure out how to make the medicine using this new particle for human consumption.
Original: http://www.sciencedaily.com/releases/2014/11/141125124802.htm
Supporting article: http://www.sciencedaily.com/releases/2013/12/131219142336.htm

Saturday, November 1, 2014

Scientists Grow Human Stomachs in Lab Dishes

sn-ministomachH.jpg (600×450)
Fluorescently labeled stomach tissue


     On Wednesday October 29, 2014 a group of researches announced the creation of a lab-grown small intestines derived from the use of stem cells.  The purpose of this creation is the ability to study gastrointestinal diseases such as stomach ulcers and stomach cancers that cannot be understood in depth previously.  Typical laboratory animals such as flies and mice have a different intestinal track and stomach in comparison to humans. Furthemore, the creation of this pea-sized stomach tissue allows researchers to get a closer look at these stomach maladies.   

     The type of stem cells used are called Pluripotent stem cells, and can ultimately turn into any cell type in the human body (i.e.- the digestive organ).  Additionally, researchers announced that they have produced the perfect recipe needed to coax both type of stem cells that have all the properties of a functional stomach, thus creating this fluorescently labeled, pea-size stomach tissue.  Ultimately, the bacterium Helicobacter Pylori, a bacterium that are blamed for many stomach ulcers and stomach cancers was exposed to the "mini stomachs" where molecular and cellular changes occurred to the stomach tissue.

     I found this article to be quite interesting because my family has been affected by both stomach cancers as well as ulcertive colitis.  I believe these findings can be extremly beneficial in the prevention of these diseases.

Main article: http://news.sciencemag.org/biology/2014/10/scientists-grow-tiny-human-stomachs-lab-dishes

Related Readings: http://www.livescience.com/48519-miniature-human-stomachs.html