In a recent study examining the genetic factors and age regarding disk herniation in mouse models, researchers may have found similarities to the condition in humans.
“Disk herniation” is when the disks in between the vertebrae of the spine protrude, which often puts pressure on the nerve and can cause extreme pain and discomfort. While this is a well documented condition in human individuals over the age of 40, mice are also capable of experiencing disk herniation. When researchers analyzed genetic markers for the condition in mice, similarities were discovered to those in humans. Transcriptomic analysis confirmed that pathways for inflammation and the activation of immune cells were similar in mice and humans and this way.
This has very large implications for the medical industry, as the more genes that are discovered in mice that create similar pathways to those for humans, the better we are able to understand human diseases and treat them.
Sources:
https://www.science.org/doi/10.1126/sciadv.ado6847
https://pubmed.ncbi.nlm.nih.gov/15879573/
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