2. DNA and the "Second Code" (Sienna Fedoruk)
This study showed an insight on the genetic code offering cells that detect inefficient genetic instructions ultimately silencing them, leading to a hidden layer of DNA control. DNA is made up of four nucleotide bases that have 3 letter codons that tell cells what protein codes for what. Scientists found that while looking at quality control using CRISPR screening they discovered a RNA-binding protein called DHX29 which interacts with the 80S ribosome. The significance of this discovery was that DHX29 associated with the ribosomes reading non-optimal codons and further works with the GIGYF2•4EHP protein complex to suppress mRNA's containing these codons and silencing them!
These new findings gave scientists a new outlook on gene regulation through codon choices playing a role in gene expression. With these findings scientists are hoping that DHX29 mechanisms could give new insights on cell differentiation, cellular balance, and cancer research.
https://www.sciencedaily.com/
Other Link: https://www.fjc.gov/content/
April 15
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