GLP-1 medications, such as Ozempic, become popular for helping people lose weight; however, the survey shows that four people use the same treatment and one of them did not respond to it. So, they do not effectively work on everyone. Recent research suggests that a person’s genes might be part of the reason. Scientists have found certain genetic variants that affect how the body responds to these drugs, particularly, humans usually have two copies of each gene, but these copies can differ. Furthermore, researchers found that people with one copy of the rs10305420 variant lost about 1.7 pounds more than those without it. And the fact is that about 40% of individuals with European and Middle Eastern ancestry carry this variant, the explanation for why people from different populations show noticeable differences in body mass when using GLP-1.
Additionally, these drugs work by targeting hormones that control appetite and blood sugar, but if someone has a specific gene variant, their body may react differently. This report is important because it could lead to more personalized treatments in the future, where genetic could be tested to predict who will benefit most from GLP-1 medications.
Source:
https://www.scientificamerican.com/article/how-well-glp-1-weight-loss-drugs-work-may-depend-on-your-genetics/
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