The building blocks of certain genes are responsible for Atopic Dermatitis (AD) diagnosis in patients. This article explores the FLG gene, which encodes for the protein filaggrin. The study found that loss of function mutations in the FLG gene are the most significant risk factor for AD. Filaggrin acts as the structural “glue” for the skin barrier. The mutations result in a defective epidermal seal which allows outside factors such as environmental triggers and food allergy to penetrate through the body.
Specifically, children with the FLG mutation are much more likely to develop eczema, which is a connecting piece for IgE-mediated food allergies. The FLG defect primes the immune system to recognize food proteins including peanuts, or eggs as dangerous invaders before the child even eats them and in an harmless state.
This study explores the links between eczema, food allergies, and even asthma which is predicted by the FLG gene. Observing these mutations early, can assist healthcare providers in prioritizing the treatment of eczema in infants to shut down the progression of food allergies or asthma.
Tags: #FLG #Eczema #Filaggrinmutations #Skinbarrier #Foodallergy
Soruces:
https://medicaljournalssweden.se/actadv/article/view/24360
https://eczema.org/information-and-advice/our-skin-and-eczema/find-out-more-about-filaggrin/
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