Recent research has uncovered why some people never seem to get COVID-19. The NIH write-up summarizes findings that certain genetic variants let the immune system clear SARS-CoV-2 before it takes hold.
In particular, work reported in Nature identifies the HLA-B*15:01 allele as strongly associated with asymptomatic infection—carriers appear to mount a rapid T-cell response that prevents illness. Researchers are also investigating CCR5-like and other resistance pathways that could limit viral entry or speed early clearance.
Together, these discoveries show that natural genetic protection is real, which helps explain wide differences in infection outcomes and points to new routes for prevention and therapy.
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