A study from March 2025 reveals new discoveries and research regarding Bipolar Disorder and how we may able to treat it with more precision in the future. The study is the largest of its kind to date, with almost 3 million control subjects and over 150,000 people with Bipolar Disorder all with different ancestries, ranging from European to African, Asian, and Latino. To identify the participants, many different methods were used, such as a self reporting survey, clinical interviews, medical records, and questionnaire data. An analysis was done to determine the frequencies of BD in each method, and it was discovered that the greatest polygenicity for BD was from the self-reports, followed by the clinical interviews and the questionnaire data respectively. It was also discovered that while Bipolar I was more heritable, the correlation between self-reporting BD I and BD was significantly lower than people with BD II self-reporting BD. 298 different loci were identified to be significant in BD, which is significantly higher than what was previously thought. People were also analyzed on an ancestral basis, with each background being found to be slightly different in identification and hereditary data.
These discoveries in genetic mapping and architecture can help identify and treat BD more effectively in the future. If we are able to identify different causes, then in the future we can identify the problem quicker and treat the disease on a per-person basis. This data could allow for everyone to be treated as their own case instead of one broad treatment for everyone. BD effects everyone differently, and with these new here hereditary links, a new foundation can be laid out to more effectively treat people based off their backgrounds and environments.
No comments:
Post a Comment