A new study published in Current Biology has revealed a rare genetic mutation that allows some individuals to feel almost no physical pain. The research, led by scientists at University College London, focuses on a woman named Jo Cameron, who has lived her whole life with painless injuries, rapid healing, and unusually low anxiety levels. The study showed that the effects were all due to a mutation in a previously unstudied region of DNA. This mutation affects a gene now known as FAAH-OUT, which regulates another gene, FAAH, involved in the body's endocannabinoid system, the same system influenced by cannabis. FAAH normally breaks down molecules related to pain sensation and mood. But with the FAAH-OUT mutation essentially turning this gene down, Cameron’s body naturally produces more of these pain reducing molecules. Because of this, she feels an almost complete insensitivity to pain, no fear before surgery, and accelerated wound healing.
Researchers believe this discovery could lead to a whole new class of painkillers that mimic this genetic effect, especially as traditional opioids continue to cause widespread addiction and overdose deaths. “This unique patient has opened a door to new pain management strategies,” said Dr. Andrei Okorokov, one of the study’s lead authors. “If we can replicate the FAAH-OUT pathway, we may eventually help patients living with chronic pain conditions.”
Interestingly, the same mutation may also be linked to lower anxiety and faster healing, though more research is needed to confirm these effects in the broader population. Scientists have already begun developing synthetic molecules that mimic this mechanism, potentially offering hope to people with neuropathic pain or PTSD.
LINK:
https://www.cell.com/article/S1074-5521(09)00080-5/fulltext
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