Immunogenetics

     In order to understand how genetic variation in genes affects the immune systems response to infections and diseases, the multidisciplinary area of immunogenetics integrates immunology and genetics. The major histocompatibility complex (MHC) genes, which are essential for the immune system's detection of foreign molecules, are the subject of this field of study. MHC molecules enable T lymphocytes to recognize and react to infections by presenting pathogen-derived peptides in the cell surface. MHC gene variations can have a substantial impact on a person's susceptibility to autoimmune disorders, infectious diseases, and even the success rate of vaccines. The significance of genetic origin in immunological health is shown by the fact that specific alleles of MHC genes have been linked to an elevated risk for diseases such as type 1 diabetes and rheumatoid arthritis. 

   Technologies like genome-wide association studies (GWAS) have accelerated recent developments in immunogenetics by enabling scientists to investigate the intricate relationship between genetic markers and immunological responses on a never-before scale. By identifying certain genetics variations connected to distinct diseases, these technologies have shed light on how different people may react to infections or therapies. Additionally, the field is establishing the groundwork for modified medicine, in which genetic profiling can guide immunization plans and treatment plans that are specific to a person's genetic composition. The capacity to anticipate disease risk, enhance treatment outcomes, and create innovative immunotherapies for cancer and other illnesses could all be improved with the increased understanding of immunogenetics. 

https://www.sciencedirect.com/topics/immunology-and-microbiology/immunogenetics

https://www.ncbi.nlm.nih.gov/books/NBK586969/