Tuesday, November 21, 2023

Review: Regeneration of the tail in lizards appears regulated by a balanced expression of oncogenes and tumor suppressors


Link to article

Tail regeneration

During stressful times, many lizards, such as a green anole will drop their tails as a deterrent to predators to leave them be. When these tails are dropped, keratinocytes will migrate to the newly dropped lizard's tail in approximately 10 days after tail amputation takes place. The upper and lower levels of the blastema are responsible for producing these onco-proteins. Although the total contents of expressed proteins are unknown, it is known that wnt2b, egfr, c-myc, fgfs, fgfr, and rhov are present in the wound. Additionally, various  tumor suppressors are present in the healing stump of the lizard. The main outcome of this research found that there were equal parts proliferative and equal parts  regenerative function of the distal tail, Researchers were looking at the patterns of gene expression and how these reptiles can grow their spinal nerves and surrounding structures back. In hopes of finding ways to treat those with paraplegia and other nerve conditions, the ability to regenerate nervous tissue is extremely beneficial in the treatment of these life long, life altering conditions. Scientists now believe that the ability to regenerate cartilage will also help advance our understanding of cartilage generation in humans. 

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