Thursday, August 3, 2023

Genetics of Type 2 Diabetes


Time-course of the discovery/initial publication of confirmed and potential type 2 diabetes risk genes. The numbers of genes identified by candidate gene approaches are represented by white bars and those of genes derived from GWA studies by black bars. Confirmed risk genes are given in black letters and potential risk genes in gray letters.

Type 2 Diabetes is a multifactorial disease and genetics also plays an important role. The people who are part of the ethnic minorities and and indigenous groups are at a higher risk of getting Type 2 Diabetes. Type 2 diabetes is considered a polygenic disease. Polygenic disease is from the effects of interactions between multiple genes. In this research, it is shown the time course of the discovery for the potential of the type 2 diabetes risk genes. The confirmed genes are in black while the potential risk genes are in gray in the picture above. There are 27 confirmed and potential type 2 diabetes susceptibility genes. 

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