Sunday, August 6, 2023

Genetic Variant May Increase Multiple Sclerosis Severity

 Multiple Sclerosis or MS is a condition in which the insulating coating of nerves and nerve fibers in the brain and the spinal cord are damaged by the immune system. This condition affects about 2.9 million people worldwide and while some people have a relapsing form of this condition, other have a severe debilitating form. Researchers have found a genetic variant that effects the speed in which MS progresses. They found that the people who inherit the condition from both parents, need a walking aid about four years sooner than those who do not which is a substantial effect on a person for a single genetic variant. Researchers analyzed data from more than 12,000 people with Multiple sclerosis and found and screening more than 7m genetic variants that associate with the speed of the condition. It was found that the genes DYSF and ZNF638 were in association with more rapid progression of the condition. While progress has been made in the past few years, new work could help with the development of therapies that could help with the severity of this disease. 

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