Friday, April 30, 2021

New CRISPR Guide RNA Screen Helps Define Genetics of Spinal Cord Regeneration in Zebrafish


In yet another interesting article by Genome Web, the highly regenerative properties of the zebrafish are explored with genomic techniques. Titled "New CRISPR Guide RNA Screen Helps Define Genetics of Spinal Cord Regeneration in Zebrafish", it is expressed that researchers based out of the University of Edinburgh have used synthetic Oligo CRISPR guide RNA's (sCrRNA) to identify functional regulators of spinal cord regeneration in the zebrafish. This of course is interesting and important science, as most vertebrates cannot regenerate damaged nervous systems, and thus, diseases such as Transverse Myelitis, Neuromyelitis Optica, Alzheimer's, Multiple Sclerosis, and Parkinson's are commonplace in human neurological pathology. Many studies note the incredible ability of zebrafish to regenerate neural tissue after direct spinal cord injuries. Following the injection of sCrRNA into the zebrafish, 30 macrophage related genes which are related to neural tissue recovery, with 10 being suggested to be explicitly related to axonal regeneration. 

If such genetic technology could be harnessed and administered on humans, it could mean the end of all neurodegenerative diseases. 

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Zebrafish Spinal Regen: 


  1. This is really amazing, using CRISPR to edit human genes with animal genes sounds like something out of a movie, I wonder what other diseases can be cured this way.

  2. The science behind this is extraordinary! using CRISPR to change certain RNA structures would be incredibly useful for so many purposes! The amount of people and diseases that could be treated is astounding! Great blog post