Peruvians Shortest People on Earth Partly Due to Gene Variant.
There are over 4000 variants in DNA that affect a person's height, each affecting the height by a millimeter or so. Peruvians were found to be the shortest people with men average height of around 5'4 and female around 5'0 ft. Almost 5% of Peruvians have a gene variant that lower height by about 2.2 centimeters. This is the biggest effect on height recorded by a common gene variant ever. If the person carried the variant from two parents they are on average shorter by 4.4 centimeters than someone who doesn't have the variant. The variant is located in the gene FBN1, which is involved in the formation of bones, connective tissue, and other tissues. there are some rare variations on the FBN1 gene that can cause Marfan Syndrome. The 5% of Peruvians that carry this gene are not considered to be "sick" or have any disorder.