With research and development of genetically modified
viruses, DNA has found a way to repair and replace defective genes in cells.
Hereditary human diseases, such as Parkinson’s disease, Huntington’s disease,
cystic fibrosis, are caused by genetic defects. One way to eradicate these traits
is through gene therapy. Using gene therapy and the development of genetically
modified viruses, DNA is introduced into cells to repair and replace defective
genes. Scientist Jens Gruber hypothesizes that the production of viruses can
efficiently boost exosome production in cells.
Scientist of the German Primate Center discover an efficient
treatment for the cells. The cell like HEK293 is used for the production of
therapeutic viruses. The protein, CD9, is produced in large quantities. This
protein helps for cell movement, cell to cell contact, and membrane fusion. The
modifications were made on the viruses used for gene transfer, for CD9 integrates
into the envelope membrane of the cell. Such process produces faster and
prevent further infection to the target cells. During gene therapy, defective genes
are replaced with functional genes, which help prevent infection of the cell. Having
the HEK293-CD9 cells allows for the exome production of CD9 proteins in the membrane,
thus allowing for the improvement for DNA transfer. During the process, genes
will be repaired and replaced using the proteins.
The results of the study show that the increased amount of
CD9 protein resulted in higher infection. As researchers further investigate,
their future findings may be a solution to prevent infection to the cells. Although
small problems arise during the study, researchers continue to find a way to enhance
and make this improvement effective.
For further information, refer to the original article.
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