
A single mitochondrion was extracted, and their DNA sequences
were analyzed. Mitochondria have their
own DNA or mtDNA, a mitochondrion can hold 10 or more different genomes. Dr. James Eberwine, extracted a single
mitochondrion and then extracted its mtDNA.
With the newly extracted mtDNA they looked at the neurons of human and
mouse cells to compare mutations of each. They discovered that the mouse cells had more
mutations than compared to the human cells.
The study showed the mutations in mtDNA in the same cell, even though
most mutations or different for the individual person. Neurons and astrocytes in the brain were also
examined in the experiment. This now
helps better understanding the limit for diseases involving increasing numbers
of mitochondrial mutations. Neurologist
will be able to diagnose neurological disease, and help detect that could potentially
harm the individual. Since mtDNA
mutations have been found to be more frequent with the elder and growing in
age, this can help them understand the conditions better. The end goal of this is to slow mtDNA
mutation accumulation so that they can potentially stop disease before they completely
form. Researchers now have a better
understanding of where to start when looking for DNA that could be affected by
a mutation.
https://www.sciencedaily.com/releases/2017/12/171206090704.htm
http://www.healthinformative.com/news-research/first-dna-sequence-single-mitochondria/
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