University of Utah (U of U) and Huntsman Cancer Institute (HCI) researchers
have discovered that lactate has an unusual role in the unusual role of lactate
in the metabolism of alveolar soft part sarcoma (ASPS). A Rare, aggressive
cancer that primarily affects adolescents and young adults. The study also
confirmed that a fusion gene is the cancer-causing agent in this disease.
There is a chromosomal translocation in ASPS tumor cells. It creates a new gene from either “parent” gene, ASPSCR1-TFE3. Every mouse that had contained this gene had developed a tumor. These tumors were also very similar to ASPS human tumors, the RNA profiles are almost identical. University of Utah(U of U) and Huntsman Cancer Institute (HCI) researchers have discovered that lactate has an unusual role inthe unusual role of lactate in the metabolism of alveolar soft part sarcoma (ASPS). rare, aggressive cancer that primarily affects adolescents and young adults. The study also confirmed that a fusion gene is the cancer-causing agent in this disease. This study can conclude that the gene ASPSCR1-TFE3 starts ASPS tumor growth.
There is a chromosomal translocation in ASPS tumor cells. It creates a new gene from either “parent” gene, ASPSCR1-TFE3. Every mouse that had contained this gene had developed a tumor. These tumors were also very similar to ASPS human tumors, the RNA profiles are almost identical. University of Utah(U of U) and Huntsman Cancer Institute (HCI) researchers have discovered that lactate has an unusual role inthe unusual role of lactate in the metabolism of alveolar soft part sarcoma (ASPS). rare, aggressive cancer that primarily affects adolescents and young adults. The study also confirmed that a fusion gene is the cancer-causing agent in this disease. This study can conclude that the gene ASPSCR1-TFE3 starts ASPS tumor growth.
http://www.sciencedaily.com/releases/2014/11/141126123921.htm
http://medicalxpress.com/news/2014-05-cancer-cells.html
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