Mong-Hong Lee has found that the
CSN6 subunit is related to Myc. The CSN6
is a protein that is similar to protein complexes in bean sprouts, which allow
the bean sprouts to grow in the dark. In humans it makes Myc, which is linked
to tumor growth, more active. Myc is
what is known as proto-oncogene (or master cancer gene) which promotes tumor growth,
as well as spurs the growth in various cancers. What happens is the CSN6 is an
oncogene (a gene that can transform a cell into a tumor cell) that is overexpressed,
speeding up tumor growth in many types of cancer.
This discovery will allow for the
development of new treatments and ways to kill tumors. The reason is mostly due to Myc has always
been challenging to deal with due to its unique protein structure. Having another protein connected to Myc will
allow us to find a new ways to combat it.
Lee’s team has found that inhibiting CSN6 quickly destabilizes Myc,
which is a vast improvement form years of studying to no avail.
The fact we are constantly advancing
and improving our treatment of cancer makes me feel hopeful. I have actually lost my father to cancer and
have always donated and raised awareness.
It fills me with joy to see progress and know we are getting closer and
closer to beating cancer. The fact we
are looking and finding genes, means not only can we beat cancer, but other
diseases as well.
Related Article: http://www.celldiv.com/content/8/1/14
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