Tuesday, November 18, 2014

Changes in single gene's action can control addiction- and depression-related behaviors

Link to the Article


Scientists have found out that regulation of a single specific gene in a brain region related to drug addiction is enough to reduce drug and stress responses. Using mouse models of human depression, stress and addiction, the scientists introduced synthetic-transcription factors into the nucleus accumbens at a gene called FosB which has been linked to addiction and depression. They found that changes to the FosB gene increased the mice's resilience to stress and made them less likely to become addicted to cocaine. Activation of FosB expression has been linked to increased sensitivity to drugs and resilience to stress.

This could be huge in helping people get over their dependency for drugs. Figuring out a way to express this gene in those struggling with drug addiction could help strengthen them and lower their "need" for whatever drug they are addicted to. Through expression of this gene, people can finally find a way to get out of their habits.

1 comment:

  1. This information can have a significant effect on a large part of Americans today. Just in New Jersey alone, especially younger generations are engaging in taking drugs and lives are being lost more often each day. The biggest issue with coming off of drugs is the ability of the patient to stay clean and remain that way for life. In a good portion of cases, at some point in their life patients are put in situations where they are offered drugs once again and unfortunately slip back into their old ways. This discovery can save so many lives on a molecular level, and permanently.

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