Tuesday, February 18, 2014

Personalized Dieting Based on an Individual's Genetic Makeup


In a recent research article published in Cell Metabolism, scientists Sean Curran and Shanshan Pang identified a collection of genes that allow an organism to adapt to different diets. This testing showed that without these genes even minor tweaks to a diet could cause premature aging and death. By finding the genetic basis of an organism’s dietary needs suggests that different individuals may be genetically predisposed to thrive on different diets. This finding could soon lead to a simple blood test that reveals which diet would work best for an individual. This could explain why some people swear a specific diet is effective yet others may find it not effective while another diet is very effective.

The organism that was studied was a one-millimeter-long worm known as Caenorhabditis elegan. This is a model organism that has shown to contain genes that are likely to be identical in humans and have a short lifespan. This makes them ideal for aging studies. Curran and Pang stated that a gene known as alh-6 delayed effects of aging depending on what type of diet the worm was fed by protecting it against diet-induced mitochondrial defects. "This gene is remarkably well-conserved from single celled yeast all the way up to mammals, which suggests that what we have learned in the worm could translate to a better understanding of the factors that alter diet success in humans," Curran said. "We hope to uncover ways to enhance the use of any dietary program and perhaps even figure out ways of overriding the system(s) that prevent the use of one diet in certain individuals.”

I believe this type of testing will prove to by very successful in the future because society is constantly trying to find easier ways to prolong the effects of aging. Many individuals have become wealthy by selling illegitimate products and services that promise significant weight loss and prevent aging. So to find that genetic background on what will actually work for individual can be extremely beneficial simply because someone may never find what specific diet works best for them. By focusing future work on identifying what contributes to dietary success or failure could be the start of something I believe could be very valuable and important to our society.



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