Researchers have identified a gene that drives the development of tumors in over one per cent of all cancer patients. This is the first time that the gene CUX1 has been broadly linked to cancer development. When CUX1 is deactivated, a biological pathway is activated that increases tumor growth. Drugs that inhibit the biological pathway are currently being used in the clinic and are in development thus highlighting a potential new targeted therapy for patients with this type of cancer-causing mutation. CUX1 is mutated at a relatively low frequency, but is associated with many different types of cancer. Because previous studies focused on genes that are mutated at a high rate in one cancer type to find cancer drivers, CUX1 was missed as a driver of cancer. Hopefully with further research, scientist can find new techniques and tactics to fight off cancers.


Red line indicates the CUX1 gene.

http://www.sciencedaily.com/releases/2013/12/131208133547.htm