Researchers at the Fred Hutchinson Cancer Research Center in Seattle, Washington have been comparing mouse models of cancer to human cancer samples. These genetically engineered mice that usually overexpress a cancer causing gene have been extensively been used to understand human cancer biology. Cancer involves a complex interplay between genetic and epigenetic alterations. the epigenetic alterations mediate changes in gene expression without altering the DNA sequences. One of these important was found to be significantly different in the mouse models of medulloblastoma and primary medulloblastoma human samples.
In my opinion, this may be an issue that needs a closer look. If researchers have found one significantly different sequences how many more can their be and even more, how different are the other sequences. I hope they go into more research to get a better understanding of the differences.
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