Laser Spotlight Reveals Machine ‘Climbing’ DNA

This article detailed current research in which revolutionary imaging technology revealed new mechanisms of “molecular machines” which served to transform genetic material through a ‘climbing’ method.  This new imaging technology works by utilizing laser lights to “generate very bright patches close to single cells.” The power of this imaging with technology is even more potent when combined with fluorescent tags which permit experts to observe the internal working of cells. Interestingly enough this technology allows experts to see in real time how “molecular machines” change the shape, size, and composition in the presence of DNA. Mark Leake  of Oxford University’s Department of Physics and David Sherratt of Oxford University’s Department of Biochemistry have collaborated on the project and the “molecular machine” in question were Structural Maintenance of Chromosome (SMC) complexes. SMC serves to transform genetic material within all living cells, and work across various vital mechanistic functions, such as permitting the contraction of muscles. To this point, technology has not been fast or precise enough for experts to observe the mechanistic tendencies of these molecules. Though now with this technology, experts have found that, as put by Leake, “'each machine functions in much the same way as rock-climber clinging to a cliff face.” Leake expanded on this thought, stating that the opening/closing action of the machine is truly a newfound process of mechanical “grabbing.” Leake and other experts remain optimistic as to how such advanced and revolutionary imaging technologies may permit examination and more complete understanding of the most vital biological processes within human systems.



After viewing the documentary on Rosalind Franklin and appreciating how revolutionary x-ray diffraction was in the determination of the structure of DNA, I am excited to see what this new type of imaging technology will bring to the current scientific field. Already experts have discussed its possible application of observing the mechanism of many of diseases currently plaguing humans. Through observation and examination of such diseases, it is very possible that experts will be able to devise a new way to combat, or even prevent, diseases afflicting countless individuals today. At its very essentials, I am excited for the wealth of knowledge and understanding that such powerful imaging technology will provide experts.