Using this antibody in mice, the researchers were able to slow down the course of the disease in the brain and the spinal cord. Multiple sclerosis is thought to result in an abnormal immune response in the brain and spinal cord. The mice that were infected with the disease were treated with the antibodies and the results showedthe Kallikrein 6 enzyme and a reduced number of the inflammatory white blood cells. Kallikrein 6 also occurs in other neurological diseases so scientists think that it is a good molecule to try other tests on.
Tuesday, May 1, 2012
Restrict the Enzyme for MS
There has been an enzyme recently found called Kallikrein 6 which is present in multiple sclerosis lesions that could be the key to curing the disease. This enzyme is associated with the inflammation in some neurodegenerative dieases, and now there may be an antibody that is able to neutralize it.

Using this antibody in mice, the researchers were able to slow down the course of the disease in the brain and the spinal cord. Multiple sclerosis is thought to result in an abnormal immune response in the brain and spinal cord. The mice that were infected with the disease were treated with the antibodies and the results showedthe Kallikrein 6 enzyme and a reduced number of the inflammatory white blood cells. Kallikrein 6 also occurs in other neurological diseases so scientists think that it is a good molecule to try other tests on.
Using this antibody in mice, the researchers were able to slow down the course of the disease in the brain and the spinal cord. Multiple sclerosis is thought to result in an abnormal immune response in the brain and spinal cord. The mice that were infected with the disease were treated with the antibodies and the results showedthe Kallikrein 6 enzyme and a reduced number of the inflammatory white blood cells. Kallikrein 6 also occurs in other neurological diseases so scientists think that it is a good molecule to try other tests on.
Labels:
enzyme,
Genetics,
multiple sclerosis
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My immunology isn't sharp, but I thought that antibodies upregulated the inflammation response? Would love some more elaboration on how antibodies downregulates inflammation in this particular instance.
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